The Opelika Chamber of Commerce was organized on January 13, 1941 and was incorporated on August 26 of that same year by Homer Carter, Yetta G. Samford, R.W. Williams, Edward M. Jones, L.A. Cherry, Isham J. Dorsey, Jr., John Thomas Frazier, J.K. Haynie, L.H. Rice, G.C. Roberts, Jr., Winston Smith T, A.L. Screws, A.C. Tatum, D.W. Ward, John L. Whatley and John D. McKibben. 

Many of these individuals' families are still in Opelika, contributing as much to the prosperity of the City as they once did.  And while the faces have changed, the goal of the Opelika Chamber of Commerce largely remains the same. 

As was recorded in the original Petition for Incorporation, it is to "promote the commercial, industrial, agricultural and civic interests of the City of Opelika and the surrounding territory; to promote integrity and good faith, just and equitable principles in business..."  In 1941, "annual dues were $12 - minimum - payble quarterly."

The Opelika Chamber has had several Presidents, but two of the more notable were William N. "Bill" Sharp, who ran the organization from 1946 through 1977 and Henry Stern, who ran it from 1977 through 1988.